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Synthesis Of Novel Substituted 2h-Thiazolo [3,2-A] Pyrimidines Using Water As Green Solvent And Their Antimicrobial Evaluation
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| dc.contributor.author | Audichya, Vipul B. | |
| dc.contributor.author | Savant, Mahesh M. | |
| dc.contributor.author | Naliapara, Yogesh T. | |
| dc.date.accessioned | 2021-08-19T10:31:37Z | |
| dc.date.available | 2021-08-19T10:31:37Z | |
| dc.date.issued | 2017-02-08 | |
| dc.identifier.citation | Audichya, V. B., Savant, M. M., & Naliapara, Y. T. (2017). SYNTHESIS OF NOVEL SUBSTITUTED 2H-THIAZOLO [3, 2-a] PYRIMIDINES USING WATER AS GREEN SOLVENT AND THEIR ANTIMICROBIAL EVALUATION. World Journal of Pharmacy and Pharmaceutical Sciences, 6(3), 775-786. | en_US |
| dc.identifier.issn | 2278–4357 | |
| dc.identifier.uri | https://www.wjpps.com/Wjpps_controller/abstract_id/6738 | |
| dc.identifier.uri | http://10.9.150.37:8080/dspace//handle/atmiyauni/710 | |
| dc.description.abstract | A novel series of N,5-bis(4-fluorophenyl)-3,5-dihydro-7-isopropyl-2H-thiazolo[3,2-a]pyrimidine -6-carboxamide has been prepared by reaction of N,4-bis(4-fluorophenyl)-1,2,3,4-tetrahydro-6-isopropyl-2-thioxopyrimidine-5-carboxamide with dibromoethane using basic catalysts TEA/ K2CO3, in the presence of TBAB/TEAB in water. We found water as an efficient and green solvent for the synthesis of novel thiazolo [3,2-a] pyrimidine scaffolds in good yields for biological interest. Among all compounds, 8c, 8g, 8i, 8l and 8o shows good antimicrobial activity against bacterial strain compare to ciprofloxacin. | en_US |
| dc.language.iso | en_US | en_US |
| dc.publisher | World Journal of Pharmacy and Pharmaceutical Sciences | en_US |
| dc.subject | Thiazolo[3,2-a]pyrimidine, Pyrimidine, Alkylation Antimicrobial evaluation. | en_US |
| dc.title | Synthesis Of Novel Substituted 2h-Thiazolo [3,2-A] Pyrimidines Using Water As Green Solvent And Their Antimicrobial Evaluation | en_US |
| dc.type | Article | en_US |
