Abstract:
We have described an easy and conventional method for the synthesis of
novel 4-hydroxy coumarin, 2-amino-6-methyl benzothiazole and arylamino bearing
1,3,5-triazine derivatives with good to high yields. The reaction of cyanuric chlorides
with coumarin afforded the intermediates under basic condition. Followed by reaction
with benzothiazole derivative and different amines under developed reaction
conditions yielded the desired trisubstituted 1,3,5-triazines 6a-n. Among the
synthesized compounds, some compounds were screened against Gram positive and
Gram negative bacteria and fungi and examined zone of inhibition. Out of them,
compound 6h has found significant against four microorganisms up to the inhibition
of 1.75 to 5.75 mm.
Description:
The authors are thankful to Shree M. & N. Virani Science College for providing
laboratory facility and Biotechnology Dept. of Pramukh swami science & H. D. Patel arts
college, Kadi for providing biological activity.
