Abstract:
An inexpensive and eco-friendly Wittig olefination protocol has been developed to prepare novel (E)-5-styrylpyrimidines. The reaction of pyrimidine phosphonium ylide with different
aryl/heteroaryl aldehydes underwent smoothly in the presence of sodium tripolyphosphate (STPP)
in aqueous condition giving (E)-5-styrylpyrimidines (10a-t) in very high yields (77-96 %).
Description:
We are thankful to the Department of Chemistry, Shree
M. & N. Virani Science College (Autonomous) Rajkot,
Bhakta Kavi Narsinh Mehta University, Junagadh, and
Saurashtra University, Rajkot for providing necessary research and literature search facilities. The authors are also
thankful to the “National Facility for Drug Discovery
through NCE’s Development and Instrumentation Support to
Small Manufacturing Pharma Enterprises” (NFDD) program
under DPRS jointly funded by the Department of Science
and Technology (DST) for spectral analysis.
