Abstract:
Herein we report a tandem cyclization protocol towards hitherto unprepared hybrid scaffolds of
coumarin and imidazole core. The synthetic methodology initiates with linking of aromatic amines with
coumarin at 4-position, followed by tandem cyclization with the help of nitromethane leading to the synthesis of title compounds in high to excellent yields (80-97%). Detailed characterization including 1
H NMR, 13C NMR and HRMS for all newly synthesized compounds has been reported
Description:
The authors are thankful to funding agencies UGC
(SAP) DRS-II & DSA-I, GOI, New Delhi, DST
(FIST-II), GOI, New Delhi, National Facility
for Drug Discovery Centre (DST-DPRP) and
Centre of Excellence in Drug Discoveryd funded
by Industries Commissionerate Gujarat (India).
The authors are also thankful to Professor and
Head at Department of Chemistry, Saurashtra
University, Rajkot for providing facilities.
