Abstract:
Novel organic based compound 4-Acyl pyrazolone derivatives and their thermal and biological
activities were investigated. A new series of Bis-pyrazolone containing ligand and their Cu(II) based
heterochelate were synthesis by various acyl chloride. The structure of bis-pyrazolone ligands were
confirmed by 1H NMR, IR, Elemental analysis and their heterochelates were confirmed by thermal
studies (TGA and DSC) and FAB Mass spectroscopy. All the synthesized compounds were screened
for their In-Vitro biological study against two Gram +ve (Bacillus cereus, Bacillus megaterium) and
two Gram-ve (E. coli, E .aerogen) microorganism. The results confirmed that novel bis-pyrazolone
based heterochelates have a great potential and significant for further investigation.
