Abstract:
Schiff base is a condensation product of primary amine and carbonyl compounds for gain the importance day by day in the present scenario. Schiff base is the compound containing azomethine or amine (-C=N-) functional group and it is found to be an inconstant pharmocophore for the design and development of some bioactive compounds. Schiff base are some of the most widely used organic compounds. They are used as pigments and dyes, catalysts, intermediates in organic synthesis, and as polymer stabilizer. Schiff base have also been shown to exhibit a broad range of biological activities, including antifungal, antibacterial, ant malarial, ant proliferative properties. Imines or azomethine groups are present in various natural, natural-derived, and non-natural compounds. The amine groups present in such compounds has been shown to be critical to their biological activities.
In this review we present the general approaches to the synthesis of Schiff base. We also highlight the most significant example of compounds belonging to this class, which exhibit anti-malarial, antibacterial, antifungal and antiviral activities to have been reported in the literature. The relationship between Schiff base and other pharmacological activities, such as ant proliferative activities, are not included in this review.
