Abstract:
A novel nitro and 2-hydroxyphenyl functionalized pyrimidinone at C5 and C6, respectively, has been synthesized using 1-(2-hydroxyphenyl)-2-nitroethanone, benzaldehyde,
urea, and etidronic acid as a catalyst is described. The synthesized compound characterized by spectroscopic techniques and finally confirmed by X-ray diffraction studies. The
molecule crystallizes in the monoclinic crystal class in the space group P21/c with cell
parameters a = 11.1070(10)Å, b = 8.8210(4)Å, c = 15.1110(13)Å, β = 106.193(2)◦,
and Z = 4. The pyrimidine ring adopts flattened boat conformation.
Description:
The authors are thankful to FIST-DST, SAP-UGC for their generous financial and instrumentation support. Special thanks are due to “National Facility for Drug Discovery through
New Chemical Entities Development & Instrumentation Support to Small Manufacturing
Pharma Enterprises” Programme under Drug & Pharma Research Support jointly funded by
DST & Government of Gujarat Industries Commissionerate. Government of India project
SP/I2/FOO/93 and University of Mysore, Mysore for financial assistance.
